Can adult-onset mito disease be episodic? Cause Dystonia?
Hi I am new here, with questions. My name is Tatia, I'm a 41-y.o. female. For 10+ years I have been experiencing both dystonia symptoms and severe weakness and fatigue, in an episodic fashion. My current neurologist thought the weakness/fatigue episodes might be periodic paralysis. Neuromuscular specialists said no, we can't find any abnormal K+ values, and tell me no disorders in their specialty would cause the dystonia. Movement disorder specialists keep telling me that dystonia can't cause weakness/fatigue. I have read, however, that mitochondrial disease can cause both.
But can it be episodic? One day I can play competitive racquetball for 45 minutes one day without any trouble. Another day, I can't even walk to the mailbox. I have episodes of severe weakness (can't raise my eyelids, can't walk except to rock my body back and forth to waddle across the room, even breathing is exhausting.) These episodes often have a trigger and an abrupt onset. Sometimes they resolve just as abruptly. I do often have mild to moderate fatigue on a regular basis, that is getting more frequent and intense as time goes by. At first, I would feel somewhat lethargic maybe 2 or 3 days a month. Now it's 4-6 days a week. But on the good days, I still have full function and energy levels.
Is dystonia ever associated with adult mitochondrial disease? And if so, is it a constant dystonia or does it come and go?
Advice would be appreciated immensely!