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Most patients with mitochondrial disease don't have an immunodeficiency.  However the stress of infectious illnesses can be associated with a prolonged period of debilitating weakness and fatigue.  Therefore preventive measures to reduce the chance of infections are worthwhile.  This can include routine and seasonal vaccinations. 

The fever and discomfort associated with inoculations could be difficult for some patients with energy disorders to endure.  These can be effectively treated using prophylactic anti-pyretics.

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