Autosomal Dominant Optic Atrophy (ADOA) is a neuro-ophthalmic condition which tends to begin in the first ten years of life and is characterized by degeneration of the optic nerves, causing visual loss. The severity of the disease is highly variable, the visual acuity ranging from normal to legal blindness. About 20% of DOA patients present with additional multi-systemic features, including neurosensory hearing loss, or less commonly chronic progressive external ophthalmoplegia, myopathy, peripheral neuropathy, multiple sclerosis-like illness, spastic paraplegia or cataracts.
https://www.ncbi.nlm.nih.gov/pubmed/22776096