Dr. Scaglia has been involved in clinical research studies that are evaluating nitric oxide flux and production in children with MELAS syndrome. This Related to the mitochondria. syndrome is associated with metabolic stroke episodes and it is thought that these episodes could reflect the effect of nitric oxide depletion in the small vasculature. By assessing nitric oxide production and the effect of arginine and citrulline supplementation in these children, potential therapeutic strategies could be offered to them. Furthermore, he is also interested in conducting glucose kinetic studies to assess the glucose metabolism and to better understand the mechanisms of diabetes in patients with this syndrome.
Dr. Scaglia is also involved in researching the identification of nuclear gene defects of pediatric mitochondrial disorders and in particular mitochondrial DNA depletion syndromes through exome sequencing. Other research interests focus on a A type of medical research study in which researchers examine how a disease or medical condition develops over time. of mitochondrial disorders in collaboration with other centers in United States of America and Canada.