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Autism and Mitochondrial Disorders: How Much Do We Really Know?

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The possible relationship between metabolic disorders, elevated lactic acid levels, and features of autism spectrum disorder have been described in the medical literature since the early 90’s.  In fact, much research exploring the correlation between autism or ASD (autism spectrum disorder) and mitochondrial dysfunctionThis is when mitochondria do not work as well as they should due to another disease or condition. Many conditions can lead to secondary dysfunction. has been published throughout the last decade, long before the Hannah Poling case (March 2008) brought the association to the public’s attention.

Since the US Vaccine Compensation Board determined, based on Hannah Poling’s case, that “vaccines significantly aggravated an underlying mitochondrialRelated to the mitochondria. disorder causing brain damage with features of autism spectrum disorder”, a whirlwind of confusion amongst parents of affected children has occurred.

Are vaccines safe?

Do children with mitochondrial disease have a potential to develop autism, or do children with autism have an underlying mitochondrial disorder?

Is mitochondrial dysfunction the “cause” of autism or behavior compatible with ASD?

What do we really know and understand about the relationship between autism spectrum disorders and mitochondrial cytopathies?

Join us as Dr. David Holtzman from Massachusetts General Hospital shares his perspective and research on the autism-mitochondrial disease debate.

Event Summary Listen Now

About the Speaker

David Holtzman, MD

Dr. Holtzman is a pediatric neurologist and has experience treating many patients with mitochondrial disease. His current research in mitochondrial physiology has recently revealed a relationship between autism and autism spectrum disorder (ASD) and abnormal mitochondrial function.

Upcoming Events

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Oct 21
8:30 pm

Our Space: A space for young adults with Mito and FAODs to connect and network

Oct 22
8:00 pm

Wondering Wednesdays with Genetic Counselor

Oct 24
12:00 pm

Weekly Support Call

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Expert Series

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Nov 7
12:00 pm - 1:00 pm

Expert Series: Two Generations of Mitochondrial Augmentation Technology: Clinical Advances in Treating Primary Mitochondrial Disease

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Last Presentation

Expert Series: Managing challenges and maximizing success in chronic mechanical ventilation
Presented September 5, 2025

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(888) 648-6228
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