Pompe Disease Russell Weller Mar 13, 2023 The disease happens when your body can’t make a protein that breaks down a complex sugar called glycogen for energy. Related Articles: Ultrasound May Help Assess Diaphragm Dysfunction in LOPD PatientsMuscle MRI Reveals Deterioration in Late-onset Pompe Patients, Study SaysPlant-based ERT May Hold Promise in Pompe Disease, Small Study Suggests