Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein

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FOCUS IS ON PARKINSON’S DISEASE: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by mitochondrial dysfunction, Lewy body formation, and loss of dopaminergic neurons. Parkin, an E3 ubiquitin ligase, is thought to inhibit PD progression by removing damaged mitochondria and suppressing the accumulation of α-synuclein and other protein aggregates. The present study describes […]