Know thy mitochondria: Autoimmunity to organelles and their DNA

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VDAC1 oligomerization forms a pore for mtDNA. Credit: Jeonghan Kim et al. National Heart Lung and Blood Institute, Bethesda, MD The immune system uses its mitochondria to self-stimulate innate and adaptive responses to infection. Reactive oxygen species (ROS), immunogenic mitochondrial DNA (mtDNA), and even whole mitochondria are locally mobilized […]