Development of a Cell-in-a-Dish Model to Study Peripheral Neuropathy in LCHADD
July 26 @ 4:00 pm – 4:45 pm
Scientists are aiming to better understand the mechanisms underlying peripheral nervous system dysfunction in LCHADD/MTPD. The limited accessibility of human neural tissues and the lack of disease-specific experimental models, mechanistic studies of peripheral neuropathy (PN) in LCHADD/MTPD remain challenging. In this presentation, Chen Zhang will introduce and explain a cell-in-a-dish platform, combining human stem cell-derived neural cells and primary rat cells to investigate the interactions/effects of circulating metabolites on neural cells and sensory neuron–Schwann cell itnteractions.
About the Speaker
Chen Zhang
Chen Zhang received her Master’s degree in Biochemistry and Molecular Biology from the University of Chinese Academy of Sciences. Prior to joining Aarhus University, she worked as a research assistant at Qilu Hospital, China, where her research focused on mitochondrial diseases.
Chen Zhang is currently a PhD student in the Department of Clinical Medicine at Aarhus University, Denmark. Her research centers on developing and applying the “LCHADD PN-in-a-dish” model in combination with biochemical analyses and multi-omics approaches to investigate fatty acid oxidation-related neuropathy. Through this work, she aims to advance the understanding of peripheral neuropathy in LCHADD and related metabolic disorders, including diabetes, and to support the development of future therapeutic strategies.
