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Expert Series: Two Generations of Mitochondrial Augmentation Technology: Clinical Advances in Treating Primary Mitochondrial Disease

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MitochondrialRelated to the mitochondria. Augmentation Technology (MAT) involves internalizing healthy, functional mitochondria into patient-derived cells to address mitochondrial dysfunctionThis is when mitochondria do not work as well as they should due to another disease or condition. Many conditions can lead to secondary dysfunction.. Minovia has developed two generations of MAT products, studied in patients with primary mitochondrial disease in collaboration with Sheba Medical Center. In this presentation, Dr. Elad Jacoby, the treating physician, and Dr. Noa Sher, Minovia’s CSO, will discuss the promises, challenges, and clinical outcomes of this innovative therapy, providing a comprehensive review of the data to date. This session offers valuable insights for patients, families, and clinicians interested in cutting-edge mitochondrial disease therapies.

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expert series, mechanical ventilation

About the Speaker

Noa Sher, Ph.D.

Noa Sher, Ph.D.

Dr. Noa Sher is Chief Scientific Officer at Minovia Therapeutics. A molecular and cellular biologist by training, she specializes in developing cell therapies for rare diseases, with expertise spanning bioinformatics, translational science, and clinical-stage product innovation. Dr. Sher has led R&D teams in academia and industry, including the design and execution of the first mitochondrial augmentation technology trials for mitochondrial diseases. She holds a PhD in Biochemistry from Hebrew University and performed postdoctoral research at the Whitehead Institute and the Technion.

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Expert Series: Managing challenges and maximizing success in chronic mechanical ventilation
Presented September 5, 2025

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