What are the Symptoms of Mitochondrial Disease?

The severity of mitochondrial disease symptoms is different from person to person. The most common symptoms are:

• Poor growth and failure to thrive (in children)

• Loss of muscle coordination, muscle weakness and pain, low tone, exercise intolerance • Neurological problems, seizures

• Autism, autistic spectrum, autism-like features

• Visual and/or hearing problems

• Developmental delays, learning disabilities

• Movement disorders

• Heart, liver or kidney disease

• Gastrointestinal disorders, including severe constipation, diarrhea, swallowing difficulty, repeated vomiting, cramping, reflux

• Diabetes

• Increased risk of infection

• Neurological issues, including difficult to treat seizures, migraines, and stroke or stroke like events

• Thyroid and/or adrenal dysfunction

• Autonomic dysfunction (may affect the functioning of the heart, bladder, intestines, sweat glands, pupils, and blood vessels

• Respiratory issues

• Lactic acidosis (the buildup of lactate in the body, which results in an excessively low pH in the bloodstream)

• Neuropsychological changes characterized by confusion, disorientation, dementia, and memory loss